Max Planck Institute for Molecular Genetics

 Department of Computational Molecular Biology

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Efficient Computational Design of Tiling Arrays Using a Shortest Path Approach

A. Schliep and R. Krause

Algorithms in Bioinformatics, Pages 383-394, Springer Berlin / Heidelberg, 2007

Genomic tiling arrays are a type of DNA microarrays which can investigate the complete genome of arbitrary species for which the sequence is known. The design or selection of suitable oligonucleotide probes for such arrays is however computationally difficult if features such as oligonucleotide quality and repetitive regions are to be considered.