Max Planck Institute for Molecular Genetics
Department of Computational Molecular Biology
The delineation of protein complexes from protein-protein interaction data is not as trivial as it may seem. We developed a simple probabilistic framework to cluster purifications while preserving the partial order relation among purifications. With a simple graph-based approach motivated by the asymmetric relationship between purifications, we can visualize overlapping components of protein complexes as supported by the experiment.
Rungsarityotin, W. and Krause, R. and Schodl, A. and Schliep, A.. Identifying protein complexes directly from high-throughput TAP data with Markov random fields (2007) [details]
Rungsarityotin, Wasinee . Algorithms to identify protein complexes from high-throughput data (2007) [details]
Contact: Wasinee Rungsarityotin (rungsari@molgen.mpg.de).