Max Planck Institute for Molecular Genetics

 Department of Computational Molecular Biology

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NOTE: We moved August 2009 to http://bioinformatics.rutgers.edu.

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Publications (2002-)

2010

B. Georgi, I. Gesteira Costa, and I. Schliep. PyMix - The Python mixture package - a tool for clustering of heterogeneous biological data. BMC Bioinformatics 2010, Vol. 11, Number 9 [details]

W. Hochstättler and A. Schliep. CATBox – An Interactive Course in Combinatorial Optimization. , Springer 2010 [details]

2009

I. G. Costa, A. Schönhuth, C. Hafemeister, and A. Schliep. Constrained Mixture Estimation for Analysis and Robust Classification of Clinical Time Series. (ISMB 2009) Bioinformatics 2009, Vol. 12, Number 25, Pages i6-14 [details] [pdf] [supp] [PMID 19478017]

B. Georgi. Context-specific Independence Mixture Models for Cluster Analysis of Biological Data. PhD Thesis Jun 2009 [details]

B. Georgi, J. Schultz, and A. Schliep. Partially-supervised protein subclass discovery with simultaneous annotation of functional residues. BMC Struct Biol. 2009, Vol. 9, Number 68 [details] [pdf] [PMID 19857261]

2008

M. C. P. de Souto, D. A. S. Araujo, I. G. Costa , R. G. F. Soares, T. B. Ludermir, and A. Schliep. Comparative Study on Normalization Procedures for Cluster Analysis of Gene Expression Datasets. Proceedings of the International Joint Conference on Neural Networks, IEEE Computer Society, 2008 [details]

M. C. P. de Souto, R. B. C. Prudencio, R. G. F. Soares, D. A. S. Araujo, I. G. Costa , T. B. Ludermir, and A. Schliep. Ranking and Selecting Clustering Algorithms Using a Meta-learning Approach. Proceedings of the International Joint Conference on Neural Networks, IEEE Computer Society, 2008 [details]

I. G. Costa, S. Roepcke, C. Hafemeister, and A. Schliep. Inferring differentiation pathways from gene expression. Bioinformatics 2008, Vol. 24, Number 13, Pages i156-164 [details] [pdf] [supp] [PMID 18586709]

A. Macula, A. Schliep, M. Bishop, and T. Renz. New, improved, and practical k-stem sequence similarity measures for probe design. J. Comput. Biol. 2008, Vol. 15, Pages 525--534 [details] [pdf] [PMID 18549305]

A. Schliep and R. Krause. Efficient algorithms for the computational design of optimal tiling arrays. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2008, Pages 557--567 [details] [pdf] [PMID 18989043]

C. Hafemeister. Efficient Computation of Probe Qualities. Master's Thesis May 2008, Freie Universität Berlin [details] [pdf]

M. de Souto, I. G. Costa, D. de Araujo, T. Ludermir, and A. Schliep. Clustering cancer gene expression data: a comparative study. BMC Bioinformatics 2008, Vol. 9, Number 1, Pages 497 [details] [pdf] [PMID 19038021]

I. G. Costa. Mixture Models for the Analysis of Gene Expression: Integration of Multiple Experiments and Cluster Validation. PhD Thesis 2008 [details]

2007

R. Schilling. Elastic registration in 3D volume data. Master's Thesis 2007, University of Freiburg [details]

I. G. Costa, M. C. P. de Souto, and A. Schliep. Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information. Advances in Bioinformatics and Computational Biology, Proceedings of the Brazilian Symposium on Bioinformatics, Pages 81-92, Springer Verlag, 2007 [details]

I. G. Costa, R. Krause, L. Optiz, and A. Schliep. Semi-supervised learning for the identification of syn-expressed genes from fused microarray and in situ image data. BMC Bioinformatics 2007, Vol. 8, Pages S3 [details] [pdf] [supp] [PMID 18269697]

I. Costa, S. Roepcke, and A. Schliep. Gene expression trees in lymphoid development. BMC Immunol 2007, Vol. 8, Number 1, Pages 25 [details] [pdf] [supp] [PMID 17925013]

B. Georgi and A. Schliep. Partially-supervised context-specific independence mixture modeling. workshop on Data Mining in Functional Genomics and Proteomics, ECML 2007, 2007 [details] [pdf]

S. Haesler, C. Rochefort, P. Licznerski, B. Georgi, P. Osten, and C. Scharff. Knockdown of FoxP2 in Songbird Basal Ganglia Impairs Song Learning. PloS Biology 2007, Vol. 5, Number 12, Pages e321 [details] [pdf]

B. Georgi, J. Schultz, and A. Schliep. Context-Specific Independence Mixture Modelling for Protein Families. Knowledge Discovery in Databases: PKDD 2007, Pages 79-90, Springer Berlin / Heidelberg, 2007 [details] [pdf] [supp]

B. Georgi, M. A. Spence, P. Flodman, and A. Schliep. Mixture model based group inference in fused genotype and phenotype data. Studies in Classification, Data Analysis, and Knowledge Organization, Springer, 2007 [details] [pdf] [supp]

G. W. Klau, S. Rahmann, A. Schliep, M. Vingron, and K. Reinert. Integer linear programming approaches for non-unique probe selection. Discrete Appl. Math. 2007, Vol. 155, Number 6-7, Pages 840-856 [details] [pdf]

L. Opitz, A. Schliep, and S. Posch. Analysis of fused in-situ hybridization and gene expression data. Proceedings of the GfKl 2006 Advances in Data Analysis, Pages 577-584, Springer, 2007 [details]

A. Schliep and R. Krause. Efficient Computational Design of Tiling Arrays Using a Shortest Path Approach. Algorithms in Bioinformatics, Pages 383-394, Springer Berlin / Heidelberg, 2007 [details] [pdf]

W. Rungsarityotin, R. Krause, A. Schodl, and A. Schliep. Identifying protein complexes directly from high-throughput TAP data with Markov random fields. BMC Bioinformatics 2007, Vol. 8, Pages 482 [details] [pdf] [supp] [PMID 18093306]

W. Rungsarityotin. Algorithms to identify protein complexes from high-throughput data. PhD Thesis 2007 [details]

2006

I. G. Costa and A. Schliep. On the feasibility of Heterogeneous Analysis of Large Scale Biological Data. Proceedings of ECML/PKDD 2006 Workshop on Data and Text Mining for Integrative Biology, Pages 55-60, 2006 [details] [pdf]

B. Georgi and A. Schliep. Context-specific independence mixture modeling for positional weight matrices. Bioinformatics 2006, Vol. 22, Number 14, Pages e166-e173 [details] [pdf] [PMID 16873468]

C. Hafemeister. Structure Learning of Conditional Trees. Bachelor's Thesis Jun 2006, Free University of Berlin [details] [pdf]

L. Opitz. Analyse von Bildern der mRNA-in Situ-Hybridisierung. Master's Thesis 2006, Martin-Luther-Universität Halle [details]

A. Schliep and S. Rahmann. Decoding non-unique oligonucleotide hybridization experiments of targets related by a phylogenetic tree. Bioinformatics 2006, Vol. 22, Number 14, Pages e424-e430 [details] [pdf] [PMID 16873503]

A. Schönhuth, I. G. Costa, and A. Schliep. Semi-supervised Clustering of Yeast Gene Expression. Accepted Japanese-German Workshop on data analysis and classification, Springer, 2006 [details]

M. Seifert. Analyzing Microarray Data Using Homogenous and Inhomogenous Hidden Markov Models. Master's Thesis 2006, Martin-Luther-Universität Halle [details]

M. Weber, W. Rungsarityotin, and A. Schliep. An indicator for the number of modes in a mixture model using a linear map to simplex structure. Proceedings of the GfKl 2005 From Data and Information Analysis to Knowledge Engineering, Pages 103-110, Springer, 2006 [details] [pdf]

2005

I. G. Costa and A. Schliep. On external indices for mixtures: validating mixtures of genes. From Data and Information Analysis to Knowledge Engineering, Pages 662-669, Springer 2005, 2005 [details] [pdf]

I. G. Costa, A. Schönhuth, and A. Schliep. The Graphical Query Language: a tool for analysis of gene expression time-courses. Bioinformatics 2005, Vol. 21, Number 10, Pages 2544-5 [details] [pdf]

B. Georgi. Mixture Modeling and Group Inference in Fused Genotype and Phenotype Data. Master's Thesis 2005, Free University of Berlin [details]

M. Heinig. Development of a Pair HMM based Gene Finder for the Paramecium Genome. Master's Thesis 2005, Free University of Berlin [details]

A. Schliep, I. G. Costa, C. Steinhoff, and A. Schönhuth. Analyzing gene expression time-courses. IEEE/ACM Trans Comput Biol Bioinform 2005, Vol. 2, Number 3, Pages 179-193 [details] [pdf] [PMID 17044182]

A. Schliep, B. Georgi, W. Rungsarityotin, I. G. Costa, and A. Schönhuth. The General Hidden Markov Model Library: Analyzing Systems with Unobservable States. Forschung und wissenschaftliches Rechnen: Beiträge zum Heinz-Billing-Preis 2004, Series GWDG-Bericht, Pages 121-135, Gesellschaft für wissenschaftliche Datenverarbeitung 2005 [details] [pdf]

J. Tödling, S. Schmeier, M. Heinig, B. Georgi, and S. Röpcke. MACAT - MicroArray Chromosome Analysis Tool. Bioinformatics 2005, Vol. 21, Number 9, Pages 2112-2113 [details]

2004

I. G. Costa, F. A. T. De Carvalho, and M. C. P. De Souto. Comparative Analysis of Clustering Methods for Gene Expression Time Course Data. Genetics and Molecular Biology 2004, Vol. 27, Number 4, Pages 623-631 [details]

J. Grunau. Discriminative Learning in Hidden Markov Models. Bachelor's Thesis 2004, Free University of Berlin [details]

G. W. Klau, S. Rahmann, A. Schliep, M. Vingron, and K. Reinert. Optimal robust non-unique probe selection using Integer Linear Programming. Bioinformatics 2004, Vol. 20 Suppl 1, Pages i186-i193 [details] [pdf] [PMID 15262798]

A. Riemer. Chromosome-wide Expression for Improving ab-initio Gene Prediction. Bachelor's Thesis 2004, Free University of Berlin [details]

W. Rungsarityotin. Graph-based clustering for biological data. Master's Thesis 2004, Free University of Berlin [details]

A. Schliep, C. Steinhoff, and A. Schönhuth. Robust inference of groups in gene expression time-courses using mixtures of HMMs. Bioinformatics 2004, Vol. 20 Suppl 1, Pages i283-i289 [details] [pdf] [supp] [PMID 15262810]

M. Weber, W. Rungsarityotin, and A. Schliep. Perron Cluster Analysis and Its Connection to Graph Partitioning for Noisy Data. , Zuse Institute Berlin (ZIB) 2004 [details]

2003

B. Georgi. A Graph-Based Approach to Clustering of Profile Hidden Markov Models. Bachelor's Thesis 2003, Free University of Berlin [details]

J. Heise. Selection of Family-Specific Probes for Microarrays. Bachelor's Thesis 2003, Free University of Berlin [details]

B. Knab, A. Schliep, B. Steckemetz, and B. Wichern. Model-Based Clustering With Hidden Markov Models and its Application to Financial Time-Series Data. Proceedings of the GfKl 2002 Between Data Science and Applied Data Analysis, Pages 561-569, Springer, 2003 [details] [pdf]

A. Schliep, A. Schönhuth, and C. Steinhoff. Using hidden Markov models to analyze gene expression time course data. Bioinformatics 2003, Vol. 19 Suppl 1, Pages i255-i263 [details] [pdf] [supp] [PMID 12855468]

A. Schliep, D. C. Torney, and S. Rahmann. Group testing with DNA chips: generating designs and decoding experiments. Proc IEEE Comput Soc Bioinform Conf 2003, Vol. 2, Pages 84-91 [details] [pdf] [PMID 16452782]

A. Weisse. Recognition of Circular Permutations in Proteins with Hidden Markov Models. Bachelor's Thesis 2003, Free University of Berlin [details]

2002

L. Kaderali and A. Schliep. Selecting signature oligonucleotides to identify organisms using DNA arrays. Bioinformatics 2002, Vol. 18, Number 10, Pages 1340-1349 [details] [pdf] [PMID 12376378]

P. Pipenbacher, A. Schliep, S. Schneckener, A. Schönhuth, D. Schomburg, and R. Schrader. ProClust: improved clustering of protein sequences with an extended graph-based approach. Bioinformatics 2002, Vol. 18 Suppl 2, Pages S182-S191 [details] [pdf] [PMID 02]

A. Schliep and W. Hochstättler. Developing Gato and CATBox with Python: Teaching graph algorithms through visualization and experimentation. Multimedia Tools for Communicating Mathematics, Pages 291-310, Springer-Verlag 2002 [details] [pdf]