Finding the genetic causes of complex diseases such as Autism and ADHD is complicated by ambiguities and subjectivities in the diagnostic process and the simultaneous involvement of multiple genes and environmental factors. We investigate the application of mixture model based clustering on fused geno- and phenotype data. This joint analysis might yield further insight into the complex interactions between geno- and phenotypes which underlie a specific disease pattern.
Georgi, B. and Spence, M. A. and Flodman, P. and Schliep, A.. Mixture model based group inference in fused genotype and phenotype data (2007) [details]
Georgi, Benjamin. Mixture Modeling and Group Inference in Fused Genotype and Phenotype Data (2005) [details]